Three new cucurbitane-type triterpenoid glycosides from Citrullus colocynthis and their anti-inflammatory activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4124-4129, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1008608
Responsible library:
WPRO
ABSTRACT
Three new cucurbitane-type triterpenoid glycosides were separated from the ethyl acetate extract of Citrullus colocynthis by a variety of chromatographic techniques. According to the data of NMR, HR-ESI-MS, and/or comparison with the reported data, the three novel cucurbitane-type triterpenoid glycosides were identified as colocynthenin E(1), colocynthenin G(2), and colocynthenin H(3). The cell inflammation model was established with RAW264.7 macrophages exposed to lipopolysaccharide and then used to determine the anti-inflammatory activities of the three compounds. Compounds 2 and 3 showed mild anti-inflammatory activities with the IC_(50) of 48.21 and 40.11 μmol·L~(-1), respectively, compared with that(IC_(50)=7.57 μmol·L~(-1)) of the positive control dexamethasone.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Triterpenes
/
Plant Extracts
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Citrullus colocynthis
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Glycosides
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Anti-Inflammatory Agents
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2023
Type:
Article