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Research progress in pharmacotherapy of insomnia / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 5122-5130, 2023.
Article in Chinese | WPRIM | ID: wpr-1008710
ABSTRACT
Insomnia is extremely common and is a risk factor for a variety of physical and psychological disorders in addition to contributing to the reduced quality of life of patients and the burden of healthcare costs. Although cognitive behavioral therapy is the first-line treatment for insomnia, its difficulty of access and high cost have hindered its application. Therefore, pharmacotherapy remains the common treatment choice for patients and clinicians. Existing chemical drugs including benzodiazepine receptor agonists, dual orexin receptor antagonists, melatonin and its receptor agonists, histamine antagonists, antidepressants, and antipsychotics are able to induce and/or maintain sleep and have good therapeutic effects on acute insomnia, but their efficacy on chronic insomnia is indefinite. Furthermore, they have several side effects and affect sleep structure and physiological function. Under the guiding principle of holistic view and treatment based on syndrome differentiation, traditional Chinese medicine(TCM) has shown a good effect in clinical practice, but with little high-grade clinical evidence. The mechanism, dose, half-life period, adjustment of sleep structure, and side effects of hypnotic drugs are key factors to be considered for clinical use. This paper analyzed and summarized the drugs for insomnia from the above aspects, and is expected to provide references for the application and development of sedative and hypnotic drugs.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Sleep / Hypnotics and Sedatives / Sleep Initiation and Maintenance Disorders / Antidepressive Agents Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2023 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Sleep / Hypnotics and Sedatives / Sleep Initiation and Maintenance Disorders / Antidepressive Agents Limits: Humans Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2023 Type: Article