Chemical constituents from Salacia polysperma / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 6676-6681, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1008865
Responsible library:
WPRO
ABSTRACT
Nine compounds were isolated from the 90% ethanol extract of Salacia polysperma by silica gel, Sephadex LH-20 column chromatography, together with preparative HPLC methods. Based on HR-ESI-MS, MS, 1D and 2D NMR spectral analyses, the structures of the nine compounds were identified as 28-hydroxy wilforlide B(1), wilforlide A(2), 1β,3β-dihydroxyurs-9(11),12-diene(3),(-)-epicatechin(4),(+)-catechin(5),(-)-4'-O-methyl-ent-galloepicatechin(6), 3-hydroxy-1-(4-hydroxy-3-methoxy-phenyl)propan-1-one(7),(-)-(7S,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneoligna-7,9-diol-7'-aldehyde(8), and vanillic acid(9). Compound 1 is a new oleanane-type triterpene lactone. Compounds 1, 3, 4, 7-9 were isolated from the Salacia genus for the first time. All compounds were assayed for their α-glucosidase inhibitory activity. The results suggested that compound 8 exhibited moderate α-glucosidase inhibitory activity, with an IC_(50) value of 37.2 μmol·L~(-1), and the other compounds showed no α-glucosidase inhibitory activity.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Triterpenes
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Ethanol
/
Salacia
/
Alpha-Glucosidases
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2023
Type:
Article