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Research progress on vascularization of organoids / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 625-631, 2023.
Article in Chinese | WPRIM | ID: wpr-1008881
ABSTRACT
Organoids are three-dimensional structures formed by self-organizing growth of cells in vitro, which own many structures and functions similar with those of corresponding in vivo organs. Although the organoid culture technologies are rapidly developed and the original cells are abundant, the organoid cultured by current technologies are rather different with the real organs, which limits their application. The major challenges of organoid cultures are the immature tissue structure and restricted growth, both of which are caused by poor functional vasculature. Therefore, how to develop the vascularization of organoids has become an urgent problem. We presently reviewed the progresses on the original cells of organoids and the current methods to develop organoids vascularization, which provide clues to solve the above-mentioned problems.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Technology / Organoids / Neovascularization, Pathologic Limits: Humans Language: Chinese Journal: Journal of Biomedical Engineering Year: 2023 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Technology / Organoids / Neovascularization, Pathologic Limits: Humans Language: Chinese Journal: Journal of Biomedical Engineering Year: 2023 Type: Article