A Proposal to Prevent the "Mephisto Sign" Side Effect of Botulinum Toxin Type A Injection in Chronic Migraine
Yonsei Medical Journal
;
: 1542-1544, 2013.
Article
in English
| WPRIM
| ID: wpr-100940
ABSTRACT
Botulinum toxin type A (BoNT-A) has been reported as an effective treatment for chronic migraine. When BoNT-A is injected on the frontalis muscle for chronic migraine, an unexpected clinical side effect called the "Mephisto sign" may occur. The aim of this article is to propose a method to eliminate or prevent the Mephisto sign side effect. A 25-year-old female patient visited the hospital and was diagnosed with chronic migraine. A total of 155 U of BoNT-A was injected into 31 sites. 2-weeks later, and the patient developed the Mephisto sign. An additional 2-U dose was administered bilaterally to the lateral-most point of the frontalis muscles, and the eyebrow morphology returned to normal within 2-3 weeks. We propose that the development of the Mephisto sign may be prevented with an additional BoNT-A injection of 2-4 U bilaterally to the lateral most point of the frontalis muscles during the primary injection process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Botulinum Toxins, Type A
/
Injections
/
Migraine Disorders
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Type:
Article
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