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The mechanism of microcystin leucine-arginine (MC-LR)-induced injury of Sertoli cell immune response and biological behavior / 细胞与分子免疫学杂志
Article in Zh | WPRIM | ID: wpr-1009427
Responsible library: WPRO
ABSTRACT
Microcystin-leucine arginine (MC-LR), a potentially carcinogenic toxin, is produced by Cyanobacteria such as Microcystis and Ananabacteria during water bloom. Increasing evidence demonstrated that MC-LR induces male reproductive toxicity, mainly by inducing germ cell apoptosis, destroying cell cytoskeleton, interfering with DNA damage repair pathway, and damaging blood-testicular barrier (BTB), which eventually lead to male sterility. Testicular Sertoli cells are the somatic cells that directly contact with spermatogenic cells in seminiferous tubules. They not only regulate immune response to maintain testicular immune homeostasis by secreting a variety of cytokines and immunosuppressive factors, but also provide the protective effects of spermatogenic cells by forming BTB. MC-LR induces inflammation and apoptosis of Sertoli cells, and destroys the integrity of the BTB, and then causes spermatogenesis dysfunction.
Subject(s)
Full text: 1 Index: WPRIM Main subject: Arginine / Sertoli Cells / Microcystins / Immunity / Leucine Limits: Humans / Male Language: Zh Journal: Chinese Journal of Cellular and Molecular Immunology Year: 2023 Type: Article
Full text: 1 Index: WPRIM Main subject: Arginine / Sertoli Cells / Microcystins / Immunity / Leucine Limits: Humans / Male Language: Zh Journal: Chinese Journal of Cellular and Molecular Immunology Year: 2023 Type: Article