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Research progress on mTOR signaling pathway and regulatory T cell nutrition metabolic regulation mechanism / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology ; (12): 69-73, 2024.
Article in Chinese | WPRIM | ID: wpr-1009477
ABSTRACT
In the tumor microenvironment, metabolic reprogramming can impact metabolic characteristics of T cells, thus inducing immunosuppression to promote tumor immune escape. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in regulating diverse functions of various immune cells. This review mainly focuses on the molecular mechanism of mTOR signaling in regulating cellular energy metabolism process, and the activation status of mTOR signaling under different nutritional environments. In addition, it also summarizes the role of the mTOR signaling in regulatory T cell (Tregs) metabolism and function in current studies, and evaluates the potential of mTOR as a clinical immunotherapeutic target and its current application challenges.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Immunosuppression Therapy / T-Lymphocytes, Regulatory / Sirolimus / TOR Serine-Threonine Kinases / Metabolic Reprogramming Limits: Humans Language: Chinese Journal: Chinese Journal of Cellular and Molecular Immunology Year: 2024 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Signal Transduction / Immunosuppression Therapy / T-Lymphocytes, Regulatory / Sirolimus / TOR Serine-Threonine Kinases / Metabolic Reprogramming Limits: Humans Language: Chinese Journal: Chinese Journal of Cellular and Molecular Immunology Year: 2024 Type: Article