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Iodinated Contrast Media Can Induce Long-Lasting Oxidative Stress in Hemodialysis Patients
Yonsei Medical Journal ; : 1438-1446, 2013.
Article in English | WPRIM | ID: wpr-100955
ABSTRACT

PURPOSE:

Due to their comorbidities, dialysis patients have many chances to undergo radiologic procedures using iodinated contrast media. We aimed to assess time-sequenced blood oxidative stress level after contrast exposure in hemodialysis (HD) patients compared to those in the non-dialysis population. MATERIALS AND

METHODS:

We included 21 anuric HD patients [HD-coronary angiography (CAG) group] and 23 persons with normal renal function (nonHD-CAG group) scheduled for CAG, and assessed 4 oxidative stress markers [advanced oxidation protein products (AOPP); catalase; 8-hydroxydeoxyguanosine; and malondialdehyde] before and after CAG, and subsequently up to 28 days.

RESULTS:

In the nonHD-CAG group, only AOPP increased immediately after CAG and returned to baseline within one day. However, in the HD-CAG group, all four oxidative stress markers were significantly increased starting one day after CAG, and remained elevated longer than those in the nonHD-CAG group. Especially, AOPP level remained elevated for a month after contrast exposure.

CONCLUSION:

Our study showed that iodinated contrast media induces severe and prolonged oxidative stress in HD patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Renal Dialysis / Oxidative Stress / Contrast Media Limits: Aged / Female / Humans / Male Language: English Journal: Yonsei Medical Journal Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Renal Dialysis / Oxidative Stress / Contrast Media Limits: Aged / Female / Humans / Male Language: English Journal: Yonsei Medical Journal Year: 2013 Type: Article