External validation and newly development of a nomogram to predict overall survival of abiraterone-treated, castration-resistant patients with metastatic prostate cancer / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 184-188, 2018.
Article
in En
| WPRIM
| ID: wpr-1009553
Responsible library:
WPRO
ABSTRACT
Abiraterone acetate is approved for the treatment of castration-resistant prostate cancer (CRPC); however, its effects vary. An accurate prediction model to identify patient groups that will benefit from abiraterone treatment is therefore urgently required. The Chi model exhibits a good profile for risk classification, although its utility for the chemotherapy-naive group is unclear. This study aimed to externally validate the Chi model and develop a new nomogram to predict overall survival (OS). We retrospectively analyzed a cohort of 110 patients. Patients were distributed among good-, intermediate-, and poor-risk groups, according to the Chi model. The good-, intermediate-, and poor-risk groups had a sample size of 59 (53.6%), 34 (30.9%), and 17 (15.5%) in our dataset, and a median OS of 48.4, 29.1, and 10.5 months, respectively. The C-index of external validation of Chi model was 0.726. Univariate and multivariate analyses identified low hemoglobin concentrations (<110 g l-1), liver metastasis, and a short time interval from androgen deprivation therapy to abiraterone initiation (<36 months) as predictors of OS. Accordingly, a new nomogram was developed with a C-index equal to 0.757 (95% CI, 0.678-0.836). In conclusion, the Chi model predicted the prognosis of abiraterone-treated, chemotherapy-naive patients with mCRPC, and we developed a new nomogram to predict the overall survival of this group of patients with less parameters.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Time Factors
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Bone Neoplasms
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Serum Albumin
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Adenocarcinoma
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Proportional Hazards Models
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Multivariate Analysis
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Survival Rate
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Retrospective Studies
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Cohort Studies
Limits:
Aged
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Aged80
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Humans
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Male
Language:
En
Journal:
Asian Journal of Andrology
Year:
2018
Type:
Article