Evaluation of PSA-age volume score in predicting prostate cancer in Chinese population / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 324-329, 2018.
Article
in English
| WPRIM
| ID: wpr-1009580
ABSTRACT
This study was performed to evaluate prostate-specific antigen-age volume (PSA-AV) scores in predicting prostate cancer (PCa) in a Chinese biopsy population. A total of 2355 men who underwent initial prostate biopsy from January 2006 to November 2015 in Huashan Hospital were recruited in the current study. The PSA-AV scores were calculated and assessed together with PSA and PSA density (PSAD) retrospectively. Among 2133 patients included in the analysis, 947 (44.4%) were diagnosed with PCa. The mean age, PSA, and positive rates of digital rectal examination result and transrectal ultrasound result were statistically higher in men diagnosed with PCa (all P < 0.05). The values of area under the receiver operating characteristic curves (AUCs) of PSAD and PSA-AV were 0.864 and 0.851, respectively, in predicting PCa in the entire population, both performed better than PSA (AUC = 0.805; P < 0.05). The superiority of PSAD and PSA-AV was more obvious in subgroup with PSA ranging from 2.0 ng ml-1 to 20.0 ng ml-1. A PSA-AV score of 400 had a sensitivity and specificity of 93.7% and 40.0%, respectively. In conclusion, the PSA-AV score performed equally with PSAD and was better than PSA in predicting PCa. This indicated that PSA-AV score could be a useful tool for predicting PCa in Chinese population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Neoplasms
/
Reference Values
/
Aging
/
Predictive Value of Tests
/
Retrospective Studies
/
ROC Curve
/
Sensitivity and Specificity
/
Prostate-Specific Antigen
/
Ultrasonography, Interventional
/
Area Under Curve
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2018
Type:
Article
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