Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 400-404, 2018.
Article
in English
| WPRIM
| ID: wpr-1009582
ABSTRACT
This study aimed to gain insight into the underlying pathogenesis of erectile dysfunction in young men under the age of 40 years without widely-known risk factors. Compared with normal controls, patients with erectile dysfunction had increased carotid intima-media thickness, fasting levels of blood glucose and insulin, and homeostatic model assessment index, as well as lower flow-mediated vasodilation and testosterone levels (P < 0.05), though all of these values were within their respective normal range. Multivariate logistic regression analysis identified carotid intima-media thickness, flow-mediated vasodilation, insulin level, and homeostatic model assessment index as significant predictors of erectile dysfunction. Young men with flow-mediated vasodilation <10.65% were 11.645 times more likely to have erectile dysfunction, young men with carotid intima-media thickness >0.623 mm had a 4.16-fold, and young men with homeostatic model assessment index >1.614 had a 5.993-fold greater risk of having erectile dysfunction. In conclusions, in young men with normal results from general clinical screening, an increased carotid intima-media thickness and homeostatic model assessment index and reduced flow-mediated vasodilation were associated with a higher incidence of erectile dysfunction. Erectile dysfunction may appear before the detection of traditional cardiovascular risk factors and may be the earliest clinical sign of subclinical cardiovascular disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Testosterone
/
Vasodilation
/
Blood Glucose
/
Carotid Artery Diseases
/
Incidence
/
Risk Factors
/
ROC Curve
/
Ultrasonography
/
Atherosclerosis
/
Carotid Intima-Media Thickness
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Asian Journal of Andrology
Year:
2018
Type:
Article
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