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Transurethral resection of the prostate is an independent risk factor for biochemical recurrence after radical prostatectomy for prostate cancer / 亚洲男科学杂志(英文版)
Asian Journal of Andrology ; (6): 217-221, 2020.
Article in English | WPRIM | ID: wpr-1009755
ABSTRACT
Biochemical recurrence (BCR) is important for measuring the oncological outcomes of patients who undergo radical prostatectomy (RP). Whether transurethral resection of the prostate (TURP) has negative postoperative effects on oncological outcomes remains controversial. The primary aim of our retrospective study was to determine whether a history of TURP could affect the postoperative BCR rate. We retrospectively reviewed patients with prostate cancer (PCa) who had undergone RP between January 2009 and October 2017. Clinical data on age, prostate volume, serum prostate-specific antigen levels (PSA), biopsy Gleason score (GS), metastasis stage (TNM), D'Amico classification, and American Society of Anesthesiologists (ASA) classification were collected. Statistical analyses including Cox proportional hazard models and sensitivity analyses which included propensity score matching, were performed, and the inverse-probability-of-treatment-weighted estimator and standardized mortality ratio-weighted estimator were determined. We included 1083 patients, of which 118 had a history of TURP. Before matching, the non-TURP group differed from the TURP group with respect to GS (P= 0.047), prostate volume (mean 45.19 vs 36.00 ml, P < 0.001), and PSA level (mean 29.41 vs 15.11 ng ml-1, P= 0.001). After adjusting for age, PSA level, T stage, N stage, M stage, and GS, the TURP group showed higher risk of BCR (hazard ratio [HR] 2.27, 95% confidence interval [CI] 1.13-3.94, P= 0.004). After matching (ratio 14), patients who underwent TURP were still more likely to develop BCR according to the adjusted propensity score (HR 2.00, 95% CI 1.05-3.79, P= 0.034). Among patients with PCa, those with a history of TURP were more likely to develop BCR after RP.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatic Neoplasms / Retrospective Studies / Risk Factors / Prostate-Specific Antigen / Transurethral Resection of Prostate / Neoplasm Grading / Neoplasm Recurrence, Local Limits: Aged / Humans / Male Language: English Journal: Asian Journal of Andrology Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prostatic Neoplasms / Retrospective Studies / Risk Factors / Prostate-Specific Antigen / Transurethral Resection of Prostate / Neoplasm Grading / Neoplasm Recurrence, Local Limits: Aged / Humans / Male Language: English Journal: Asian Journal of Andrology Year: 2020 Type: Article