Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 745-748, 2020.
Article
in English
| WPRIM
| ID: wpr-1010553
ABSTRACT
Piper betle (PB), also known as "betel" in Malay language, is a tropical Asian vine. PB leaves are commonly chewed by Asians along with betel quid. It contains phenols such as eugenol and hydroxychavicol along with chlorophyll, β-carotene, and vitamin C (Salehi et al., 2019). Extracts from PB leaves have various medicinal properties including anticancer, antioxidant, anti-inflammatory, and antibacterial effects (Salehi et al., 2019). Previous research has shown that PB induces cell cycle arrest at late S or G2/M phase and causes apoptosis at higher doses (Wu et al., 2014; Guha Majumdar and Subramanian, 2019). A combination of PB leaf extract has also been shown to enhance the cytotoxicity of the anticancer drug, 5-fluorouracil (5-FU), in cancer cells (Ng et al., 2014).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plant Extracts
/
Cell Movement
/
Plant Leaves
/
HT29 Cells
/
Piper betle
/
Microtubules
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2020
Type:
Article
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