Advances and Applications of Brain Organoids / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 1703-1716, 2023.
Article
in English
| WPRIM
| ID: wpr-1010631
ABSTRACT
Understanding the fundamental processes of human brain development and diseases is of great importance for our health. However, existing research models such as non-human primate and mouse models remain limited due to their developmental discrepancies compared with humans. Over the past years, an emerging model, the "brain organoid" integrated from human pluripotent stem cells, has been developed to mimic developmental processes of the human brain and disease-associated phenotypes to some extent, making it possible to better understand the complex structures and functions of the human brain. In this review, we summarize recent advances in brain organoid technologies and their applications in brain development and diseases, including neurodevelopmental, neurodegenerative, psychiatric diseases, and brain tumors. Finally, we also discuss current limitations and the potential of brain organoids.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Organoids
/
Neurodegenerative Diseases
/
Disease Models, Animal
/
Induced Pluripotent Stem Cells
Limits:
Animals
/
Humans
Language:
English
Journal:
Neuroscience Bulletin
Year:
2023
Type:
Article
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