Phase separation in cGAS-STING signaling / 医学前沿
Frontiers of Medicine
;
(4): 855-866, 2023.
Article
in English
| WPRIM
| ID: wpr-1010821
ABSTRACT
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Signal Transduction
/
Phase Separation
/
Membrane Proteins
/
Nucleotidyltransferases
Limits:
Humans
Language:
English
Journal:
Frontiers of Medicine
Year:
2023
Type:
Article
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