Your browser doesn't support javascript.
loading
Biotransformation differences of ginsenoside compound K mediated by the gut microbiota from diabetic patients and healthy subjects / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 723-729, 2023.
Article in English | WPRIM | ID: wpr-1010985
ABSTRACT
Many natural products can be bio-converted by the gut microbiota to influence pertinent efficiency. Ginsenoside compound K (GCK) is a potential anti-type 2 diabetes (T2D) saponin, which is mainly bio-transformed into protopanaxadiol (PPD) by the gut microbiota. Studies have shown that the gut microbiota between diabetic patients and healthy subjects are significantly different. Herein, we aimed to characterize the biotransformation of GCK mediated by the gut microbiota from diabetic patients and healthy subjects. Based on 16S rRNA gene sequencing, the results indicated the bacterial profiles were considerably different between the two groups, especially Alistipes and Parabacteroides that increased in healthy subjects. The quantitative analysis of GCK and PPD showed that gut microbiota from the diabetic patients metabolized GCK slower than healthy subjects through liquid chromatography tandem mass spectrometry (LC-MS/MS). The selected strain A. finegoldii and P. merdae exhibited a different metabolic capability of GCK. In conclusion, the different biotransformation capacity for GCK may impact its anti-diabetic potency.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: RNA, Ribosomal, 16S / Biotransformation / Chromatography, Liquid / Diabetes Mellitus, Type 2 / Tandem Mass Spectrometry / Feces / Healthy Volunteers / Gastrointestinal Microbiome Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2023 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: RNA, Ribosomal, 16S / Biotransformation / Chromatography, Liquid / Diabetes Mellitus, Type 2 / Tandem Mass Spectrometry / Feces / Healthy Volunteers / Gastrointestinal Microbiome Limits: Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2023 Type: Article