Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 852-858, 2023.
Article
in En
| WPRIM
| ID: wpr-1010996
Responsible library:
WPRO
ABSTRACT
We reported the discovery of six novel coumarins, toddasirins A-F (1-6), each endowed with modified isoprenyl or geranyl side chains, derived from the roots of Toddalia asiatica. Comprehensive structural elucidation was achieved through multispectroscopic analyses, single-crystal X-ray diffraction experiments, and advanced quantum mechanical electronic circular dichroism (ECD) calculations. Furthermore, the anti-inflammatory activity of these compounds was assessed. Notably, compounds 1-3 and 6 demonstrated notable inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with 50% inhibitory concentration (IC50) values of 3.22, 4.78, 8.90, and 4.31 μmol·L-1, respectively.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plant Extracts
/
Molecular Structure
/
Coumarins
/
Rutaceae
/
Anti-Inflammatory Agents
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2023
Type:
Article