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Application of a polygenic risk score in the early prediction of myopia in children and adolescents / 中国学校卫生
Chinese Journal of School Health ; (12): 148-152, 2024.
Article in Zh | WPRIM | ID: wpr-1011426
Responsible library: WPRO
ABSTRACT
Abstract@#Myopia has become a major public health issue of global concern. Scientific and effective myopia prediction models can help identify high risk groups for myopia, thereby achieving precise prevention. With the rapid development of genome wide association studies and the establishment of large scale prospective population cohorts, the polygenic risk score (PRS) model has been used to predict myopia phenotypes, advancing the myopia prediction window and thus predicting high myopia risk for early screening and intervention for at risk groups. The review aims to systematically elaborate the identification and verification of myopia genes in recent years, briefly describe the practice and effectiveness evaluation of the PRS model in myopia prevention research at home and abroad, reveal the application value in myopia prediction research, and emphasize the relationship between the PRS prediction model and outdoor activities. Close eye use and other preventive measures are of great significance to promote the precise prevention of myopia in children and adolescents.
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Index: WPRIM Language: Zh Journal: Chinese Journal of School Health Year: 2024 Type: Article
Search on Google
Index: WPRIM Language: Zh Journal: Chinese Journal of School Health Year: 2024 Type: Article