A prospective cohort study on the effect of respiratory diseases on the mortality risk of the Chinese elderly / 西安交通大学学报(医学版)

ABSTRACT

【Objective】 To explore the effect of respiratory diseases on the mortality risk of the elderly in China. 【Methods】 Totally 12 946 elderly people interviewed by The Chinese Longitudinal Healthy Longevity Survey （CLHLS） in 2008 were taken as the research objects. The elderly in this cohort were followed up until 2018. The effect of respiratory diseases on the risk of mortality in the elderly was analyzed by constructing Cox proportional risk model， and heterogeneity was analyzed by gender and age groups. 【Results】 Compared with the elderly without respiratory diseases， respiratory diseases significantly increased the risk of mortality in the elderly. Specifically， after adjusting for confounding factors， respiratory diseases increased the overall mortality risk of the elderly by 22% （HR=1.22， 95% CI： 1.14-1.30）， and self-rated respiratory diseases with little or great impact on their own life increased the mortality risk of the elderly by 18% （HR=1.18， 95% CI： 1.09-1.29） and 31% （HR=1.31， 95% CI： 1.18-1.46）， respectively. Heterogeneity analysis showed that respiratory diseases increased the risk of mortality in male and female elderly by 32% （HR=1.32， 95% CI： 1.21-1.45） and 11% （HR=1.11， 95% CI： 1.01-1.23）， respectively. Respiratory diseases increased the risk of mortality in the groups aged 65-79 years and 80-94 years by 49% （HR=1.49， 95% CI： 1.26-1.76） and 21% （HR=1.21， 95% CI： 1.26-1.76）， respectively. However， they did not significantly affect the risk of mortality in the group aged 95-104 years （HR=1.09， 95% CI： 0.97-1.23）. 【Conclusion】 Respiratory disease is an important risk factor that accelerates the mortality of the elderly， and the impact of respiratory diseases on the mortality risk of the male elderly is greater than that of the female counterparts， and the impact on the mortality risk of the young elderly is greater than that of the elderly.