Comprehensive geriatric assessment can predict the clinical outcomes of elderly patients with diffuse large B cell lymphoma in China / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 271-276, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-1011743
ABSTRACT
Objective:
To validate comprehensive geriatric assessment (CGA) system in Chinese elderly diffuse large B cell lymphoma (DLBCL) patients.Methods:
Patients ≥ 65 years of age who had been diagnosed with de novo DLBCL were screened for eligibility (n=99). CGA was performed during staging procedures through application of the following instruments age, comorbidity score according to the Cumulative Illness Rating Score for Geriatrics(CIRS-G), activities of daily living (ADL), and instrumental activities of daily living (IADL).Results:
All patients were classified as "ft" , "unfit" , and "frail" . Forty-nine (49.5%), 14 (14.1%), and 34 (36.4%) patients were categorized into the fit, unfit, and frail groups, respectively. The overall response rate was 91.8%, 64.3%, and 69.5% in fit, unfit, and frail group, respectively (χ(2)=9.311, P=0.007). Eleven (22.4%), 7 (50.0%), and 16(44.4%) patients showed disease relapse/progression in fit, unfit, and frail group, respectively (χ(2)=6.309, P=0.040). The 2-year probability of overall survival was 90.6%, 43.0%, and 58.5% in fit, unfit, and frail group, respectively (χ(2)=14.774, P=0.001). The 2-year probability of progression-free survival was 72.9%, 32.5%, and 37.3% in fit, unfit, and frail group, respectively (χ(2)=11.038, P=0.004).Conclusion:
The CGA index can predict the clinical outcomes of elderly DLBCL patients in China.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Activities of Daily Living
/
Antineoplastic Combined Chemotherapy Protocols
/
Geriatric Assessment
/
China
/
Lymphoma, Large B-Cell, Diffuse
/
Treatment Outcome
/
Neoplasm Recurrence, Local
Limits:
Aged
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2018
Type:
Article
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