Age-related clinical characteristics and prognosis in non-senile adults with acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 969-976, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-1011900
ABSTRACT
Objective:
To explore age-related clinical characteristics, early responses and outcomes in non-senile adults with de novo acute myeloid leukemia (AML).Methods:
Data of consecutive cases of 18-65 years adults with de novo AML (non-acute promyelocytic leukemia) were reviewed retrospectively. Clinical characteristics at diagnosis, early responses and outcomes across different age groups of patients were analyzed.Results:
1 097 patients were enrolled. 591 (53.9%) were male. Median age was 42 years. Increasing age was significantly associated with decreasing WBC count (P=0.003), increasing PLT count (P=0.034), lower blast proportions in bone marrow (P=0.021). The incidence of NPM1(+)/FLT3-ITD(-) increased with age (P<0.001). Multivariate analyses showed that increasing age was associated with low probabilities of achieving morphologic leukemia free state (MLFS) (P=0.053) and complete remission (CR) (P=0.004) and poor overall survival (OS) (P=0.070) in the whole patients population. However, increasing age was not associated with low MLFS rate and poor OS, except low CR rate (P=0.075) in those receiving standard induction regimen instead of low-intensity regimen.Conclusions:
There were significant differences on clinical characteristics, cytogenetics and molecular genetics across different age groups in non-senile adults with de novo AML. In the patients receiving standard induction regimen, age was not associated with MLFS rate and OS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Remission Induction
/
Leukemia, Myeloid, Acute
/
Retrospective Studies
/
Fms-Like Tyrosine Kinase 3
/
Nucleophosmin
/
Mutation
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2018
Type:
Article
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