Clinical features and risk factors of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 187-190, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-1011955
ABSTRACT
Objective:
To explore the relative risk factors, clinical intervention and prognosis of hemorrhagic cystitis (HC) in patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT) .Methods:
From January 1 2010 to May 31 2017, 425 patients with allo-HSCT received a retrospective analysis.Results:
①Among the 425 patients, 262 were male and 163 were female. The median age was 26 (2-56) years old. There were 138 cases of acute myeloid leukemia (AML) , 96 cases of acute lymphoblastic leukemia (ALL) , 29 cases of myelodysplastic syndrome (MDS) , 98 cases of severe aplastic anemia (SAA) and 64 cases of chronic myeloid leukemia (CML) . 221 cases of sibling match transplantation, 89 cases of unrelated donor transplantation and 115 cases of haplotype transplantation. ②108 patients (25.41%) developed HC, with the median time of onset of 32 (3-243) days and the median duration of 20 (3-93) days; 33 cases (30.56%) were grade Ⅰ, 49 cases of grade Ⅱ (45.36%) , 21 cases (19.44%) of grade Ⅲ, and 5 cases (4.63%) of grade Ⅳ. ③103 cases of HC were cured, 5 patients were ineffective, 12 patients died and died of transplantation related complications (infection, recurrence, severe acute GVHD, secondary implant failure) . ④Univariate analysis showed that age < 30, type of transplantation, CMV and acute GVHD were associated with the occurrence of HC after allo-HSCT. Multivariate analysis showed that acute GVHD was an independent risk factor for HC after allo-HSCT.Conclusion:
Prognosis of HC after allo-HSCT was better after timely treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retrospective Studies
/
Risk Factors
/
Hematopoietic Stem Cell Transplantation
/
Cystitis
/
Graft vs Host Disease
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2019
Type:
Article
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