Evaluation of Maternal Toxicity in Rats Exposed to Multi-Wall Carbon Nanotubes during Pregnancy
Environmental Health and Toxicology
;
: e2011006-2011.
Article
in English
| WPRIM
| ID: wpr-101240
ABSTRACT
OBJECTIVES:
The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats.METHODS:
MWCNTs were orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0, 8, 40, 200, and 1000 mg/kg/day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, oxidant-antioxidant status, gross findings, organ weights, and Caesarean section findings were examined.RESULTS:
All animals survived to the end of the study. A decrease in thymus weight was observed in the highest dose group. However, maternal body weight, food consumption, serum biochemical parameters, and oxidant-antioxidant balance in the kidneys were not affected by treatment with MWCNTs. No treatment-related differences in gestational index, embryo-fetal mortality, or fetal and placental weights were observed between treated and control groups.CONCLUSIONS:
The results show that 14-day repeated oral dosing of MWCNTs during pregnancy induces minimal maternal toxicity at 1000 mg/kg/day in rats. Under these experimental conditions, the no-observed-adverse-effect level of MWCNTs is considered to be 200 mg/kg/day for dams and 1000 mg/kg/day for embryonic development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Thymus Gland
/
Weights and Measures
/
Biochemistry
/
Body Weight
/
Carbon
/
Cesarean Section
/
Oxidative Stress
/
Maternal Exposure
/
No-Observed-Adverse-Effect Level
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Environmental Health and Toxicology
Year:
2011
Type:
Article
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