Dendropanax morbifera Léveille extract ameliorates D-galactose-induced memory deficits by decreasing inflammatory responses in the hippocampus / 한국실험동물학회지
Laboratory Animal Research
;
: 283-290, 2017.
Article
in English
| WPRIM
| ID: wpr-101365
ABSTRACT
In the present study, we examined the effects of Dendropanax morbifera Léveille leaf extract (DML) on D-galactose-induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus. Administration of DML to D-galactose-treated mice significantly improved D-galactose-induced reduction in escape latency, swimming speed, and spatial preference for the target quadrant. In addition, administration of DML to D-galactose-treated mice significantly ameliorated the microglial activation and increases of IL-1β, IL-6, and TNF-α levels in the hippocampus. Administration of D-galactose significantly reduced IL-4 levels in the hippocampus, while administration of DML to D-galactose-treated mice significantly increased IL-4 level. However, we did not observe any significant changes in IL-10 levels in hippocampal homogenates. These results suggest that DML reduces D-galactose-induced mouse senescence by reducing pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, as well as increasing anti-inflammatory cytokine IL-4.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swimming
/
United Nations
/
Aging
/
Cytokines
/
Interleukin-4
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Interleukin-10
/
Microglia
/
Galactose
Limits:
Animals
Language:
English
Journal:
Laboratory Animal Research
Year:
2017
Type:
Article
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