Protein phosphorylation involved in psychedelic-induced head-twitch response in rats / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1899-1904, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1013690
Responsible library:
WPRO
ABSTRACT
Aim To investigate the potential protein post-translational modifications of psychedelic-induced Head-twith response and underling mechanism. Methods Psychedelics LSD, DOM, or Psilocin was administered to rats by intraperitoneal injection to induce head-twitch response, then the most effective dosage was identified to create animal models of head-twitch behavior. Western blot was performed in detecting the protein phosphorylation, acetylation, and ubiquitination in prefrontal cortex of SD rats after 10 min or 30 min injection. Results LSD (0.025 mg • kg~, i. p.), DOM (3 mg•kg
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2023
Type:
Article