Roles of HO-l/PGC-1 a pathway in regulating mitochondrial oxidative stress / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 1137-1141, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-1014025
ABSTRACT
Mitochondria play central roles in energy homeosta¬sis, metabolism and signaling.Drugs may induce mitochondrial oxidative stress, disturb mitochondrial toxicity pathways and im¬pair mitochondrial function.Mitochondrial function is regulated by multiple toxicity pathways, and the antioxidant stress pathway HO-l/PGC-1 a plays an important role in mitochondrial oxidative stress.This artical reviews the influence of oxidative stress on toxicity pathways and the roles of HO-l/PGC-1 a pathway in reg¬ulating mitochondrial oxidative stress.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2022
Type:
Article
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