Recent progress on neuroprotective mechanisms of tanshinone in Alzheimer's disease / 中国药理学通报

ABSTRACT

Aim Tanshinones, lipophilic diterpenes isolated from the rhizome of Salvia miltiorrhiza, have diverse pharmaco¬logical activities against Alzheimer's disease (AD).Recently tanshinones have been the most widely studied phytochemicals for their neuroprotective effects against experimental models of AI).Recent studies have shown that tanshinones can inhibit choli nest erase activity, regulate generation and aggregation of beta-amyloid, regulate tail phosphorylation and exert anti-inflam¬matory effects, thereby playing a neuroprotective role in AI).'Hie present study aims at reviewing experimental studies and de¬scribing the possible underlying molecular mechanisms by which tanshinones and releated compounds protect against AD.