The estrogen-like protective effect of quercetin on Aβ / 中国药理学通报

ABSTRACT

Aim To investigate the protective effect of quercetin ( Que) through estrogen receptor a ( ERa ) on Ap25-35-induced mitochondrial damage in PC 12 cells.Methods PC 12 cells were selected as the ob¬ject of AD cytotoxic injury model.A(B25.35(20 (xmol • L 1 ) toxic injury was used and Que (40, 60, 80 (xmol • L 1 ) was added; meanwhile, 0.1 (xmol • L 1 17(3- estradiol ( 17f}-E2 ) and 50 (xmol • L 1 genistein ((yen) were used as positive control, and an 1C1182, 780 ( estrogen receptor inhibitor) pretreatment group (aP25 - 35 + 1 M-mo1 ' L_l ICI182,780, Ap25 35 + 1 (xmol • L"1 ICI182,780 +60