Endothelial cell energy metabolism and pathological angiogenesis / 中国药理学通报

ABSTRACT

Angiogenesis,the formation of new blood vessels from the development of existing capillaries or posterior capillar)' veins,is a key event in various physiological and pathological en-vironments.In recent years,the role of endothelial cell metabo¬lism in pathological angiogenesis has attracted much attention.More and more studies have shown that endothelial angiogenesis switches and pathological angiogenesis are regulated by key fac¬tors of energy metabolism.'Hie unique glycolysis properties of endothelial cells are essential for cell proliferation,migration and response to environmental changes.In this review, we provide an overview of recent research on endothelial cell energy metabolism and summarize and discuss the potential therapeutic strategies u- sing endothelial cell metabolism to provide some reference for dnjg development targeting endothelial cell metabolism.