Progress in RIPK3-mediated necroptosis involved in myocardial ischemia-reperfusion injury / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 641-644, 2022.
Article
in Zh
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| ID: wpr-1014200
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ABSTRACT
Aim Timely re establishment of coronary blood How in patients with myocardial infarction is the cornerstone of their treatment; however, substantial amount of damage can oecur as a consequence of reperfusion.In recent years it has been found that receptor interacting protein kinase 3 ( RIPK3 ) contributes remarkably to myocardial ischemia-reperfusion injury (MIRI).RIPK3 can regulate necroptosis through RIPK1/RIPK3/MLKL and CaMKII, respectively, and participate in the MIRI process.This artiele reviews the researeh progress of RIPK3-mediated ne¬ croptosis involved in MIRI from endoplasmic reticulum stress, mitochondrial fragmentation disturbanee, cardiac microvascular dysfunction and inflammation, and focuses on whether RIPK3 can be used as a new target for anti-MIRI, so as to provide a new strategy and choice for improving the clinical treatment effect and prognosis of ischemic heart disease.
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Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2022
Type:
Article