Rosuvastatin relieves neuronal mitochondrial damage by regulating UCP2-SIRT3 pathway after cerebral ischemia/reperfusion / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12): 52-61, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-1014293
ABSTRACT
Aim To explore the biological role and related mechanism of rosuvastatin (RS) in mitochondrial damage of neurons after cerebral ischemia/reperfusion (CIR) through UCP2-SIRT3 signaling pathway. Methods Human neuroblastoma cell (SH-SY5Y cell) cerebral infarction reperfusion model (OGD/R) was established, different concentrations of RS (40 and 2. 5 (mol • L
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2021
Type:
Article
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