Evodiamine induces apoptosis of leukemia cell line K562 VIA modulation of TRIB2/AKT pathway

Feng-Lin MOU; Bei-Zhong LIU; Jian LI; Liang ZHONG; Jiao YE; Bei-Zhong LIU; Li-Hua YU; Wen-Ran DAN; Ling XIONG

Evodiamine induces apoptosis of leukemia cell line K562 VIA modulation of TRIB2/AKT pathway / 中国药理学通报

Feng-Lin MOU; Bei-Zhong LIU; Jian LI; Liang ZHONG; Jiao YE; Bei-Zhong LIU; Li-Hua YU; Wen-Ran DAN; Ling XIONG.

Chinese Pharmacological Bulletin ; (12): 118-124, 2021.

Article in Chinese | WPRIM | ID: wpr-1014302

ABSTRACT

ABSTRACT

Aim To investigate the effects of Evodiamine (EVO) on proliferation and apoptosis of human leukemia cell line K562 and its potential mechanisms. Methods K562 cells were treated with EVO at different concentrations (0, 1, 2, 4, 8, 16, 32, 64 jxmol • L

AKT; apoptosis; evodiamine; K562 cell; proliferation suppression; TRIB2

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2021 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 2021 Type: Article