Mechanism of Tibetan medicine Lagotisbrachystachys Maxim in treatment of chronic alcoholic liver injury and acute gouty arthritis based on network pharmacological and molecular docking / 中国药理学通报

ABSTRACT

Aim To explore the common mechanism of Lagotisbrachystachys Maxim in treating chronic alcoholic liver injury and acute gouty arthritis. Methods TCMSP, CTD database and the related literature were used to obtain the chemical composition and target of Lagotisbrachystachys Maxim, combined with the data of Gene Cards, OMIM to screen the common target; an active ingredient-disease-common target network diagram was constructed, GO, KEGG enrichment analysis were performed and molecular docking were carried out to verify the binding of components and common target. Results Seven compounds in Lagotisbrachystachys Maxim could act on 253 common targets to exert their therapeutic effects; 20 key targets, such as IL-6, ALB, TNF, TP53, VEGFA, STAT3, CXCL8 and IL- 10, and 44 signaling pathways, such as Toll-like receptor signaling pathway, nod-like receptor signaling pathway, JAK-STAT signaling pathway, FcϵRI signaling pathway and PPAR signaling pathway, were used to treat the two diseases. The results of molecular docking showed that bicuculline, chryseriol and luteolin might be effective compounds for treating the two diseases. Conclusions Through a preliminary analysis of the common molecular mechanism of Lagotisbrachystachys Maxim in the treatment of chronic alcoholic liver injury and acute gouty arthritis, this study provides i-deas for future research on the mechanism of action.