Research on mechanism of abnormal cerebrovascular cell communication and brain diseases / 中国药理学通报

ABSTRACT

Brain diseases such as stroke, Alzheimer s disease, epilepsy, have always been worldwide problems that endanger human health and are costly disease from societal perspectives. In recent years, more and more attention has been paid to the relationship between components of neurovascular unit (cerebrovascular endothelial cell, microglia, astrocyte and neuron) and brain diseases. Not only have their structures changed during the pathological process, but also coupling communication and functions have changed accordingly. On the basis of summarizing previous studies on the abnormalities in intercellular communication and its mechanism with brain disorders, this review is expected to find novel targets or therapeutic treatment for neuropsychiatric diseases.