Prediction of Prognosis to Concurrent Chemo-Radiotherapy by Standardized Uptake Value of 2-18F Fluoro-2-Deoxy-D-Glucose for Nasopharyngeal Carcinomas / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology
;
: 9-16, 2005.
Article
in Korean
| WPRIM
| ID: wpr-101443
ABSTRACT
PURPOSE:
To prospectively evaluate the use of positron emission tomography with the glucose analog fluorodeoxyglucose (FDG-PET) to predict disease-free survival (DFS) after concurrent chemo-radiotherapy (CCRT) in patients with non-disseminated nasopharyngeal carcinoma (NPC). MATERIASL ANDMETHODS:
We studied 41 patients with non-disseminated NPC scheduled to undergo platinum- based CCRT were eligible for this study. Patients were studied by FDG-PET prior to the CCRT. FDG uptake of tumors were measured with the maximal standardized uptake value (SUV).RESULTS:
Complete response rate was 100%. In ten patients who presented with any component of treatment failure, the median SUVmax was 8.55 (range 2.49~14.81) in any component of failure and the median SUVmax was 6.48 (range 2.31~26.07) in the remaining patients without any such failure. Patients having tumors with high FDG uptake had a significantly lower 3-year DFS (51% v 91%, P=0.0070) compared with patients having low uptake tumors.CONCLUSION:
FDG uptake, as measured by the SUV, has potential value in predicting DFS in NPC treated by CCRT. High FDG uptake may be a useful parameter for identifying patients requiring more aggressive treatment approaches.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Prospective Studies
/
Treatment Failure
/
Disease-Free Survival
/
Positron-Emission Tomography
/
Glucose
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Society for Therapeutic Radiology and Oncology
Year:
2005
Type:
Article
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