Research progress of chronic diseases in hyperandrogenized animal models / 中国药理学通报

ABSTRACT

Chronic disease is defined as a persistent, recurrent illness with long course. Common symptoms include insulin resistance, dyslipidemia, chronic inflammation, and so on. It is well known that chronic dehydroepiandrosterone (DHEA) or dihydrotestosterone (D H T) exposure induces symptoms in rats or mice. These animals possess characteristics of obesity, ovarian dysfunction, vascular endothelial dysfunction, inflammation, and so on. In addition, DHT-treated animals have been used to explore insulin resistance, dyslipidemia, and biorhythm disorder. DHEA-treated animals were fit to detect ovarian stress. Although DHEA-treated animals does not apply to studies of metabolic diseases such as hyperlipidemia, DHEA-treated animals under high fat diet represent the related phenotypes. Based on the previous research, it can be predicted that new achievements will be made in endometrial development, ovarian cell function, inflammation modulation, atherosclerotic, and biorhythm disorder by using these hyperandrogenic animal models.