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Involvement of autophagy in iron ion regulation promotes ferroptosis in cells undergoing intestinal ischemia-reperfusion injury / 中国临床药理学与治疗学
Article in Zh | WPRIM | ID: wpr-1014696
Responsible library: WPRO
ABSTRACT
AIM: To investigate the effect of autophagy on cell ferroptosis in intestinal ischemia-reperfusion injury. METHODS: Twenty-four SPF grade Wistar rats weighing 200-220 g were divided into 4 groups (n = 6): sham operation group (sham group), ischemia group (I group), ischemia-reperfusion group (I/R group),and ischemia-reperfusion + autophagy inhibitor group (I/R + 3-MA group). The ischemia model was established by clamping the superior mesenteric artery for 1 hour, and the intestinal ischemia-reperfusion injury model was established by reperfusion for 2 hours. HE staining was used to observe the pathological changes of intestinal mucosa and Chiu score under light microscope. Fe
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Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Clinical Pharmacology and Therapeutics Year: 2023 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Clinical Pharmacology and Therapeutics Year: 2023 Type: Article