Research progress of transient receptor potential ion channels and psoriasis / 中国临床药理学与治疗学

ABSTRACT

The occurrence of psoriasis mainly involves abnormal cellular immune system and the abnormal proliferation and differentiation of keratinocytes. Recent studies have found that transient receptor potential (TRP) ion channels are related to the etiology of psoriasis and play an important role in the pathophysiological process of psoriasis. Using inhibitors or activators of partial TRP channels can improve or alleviate the symptoms of psoriasis, suggesting that partial TRP channels may be new targets for psoriasis treatment. This article mainly reviews the relationship between TRP channels and etiology of psoriasis, and the research advancement of TRP channels as treatment targets for psoriasis.