Application of pharmacomicrobiomics in new drug development / 中国临床药理学与治疗学

ABSTRACT

Pharmacogenomics promotes the success rate and efficiency of new drug development by targeting host genes. However, host gene level cannot fully explain the difference of drug efficacy among individuals. Pharmacomicrobiomics is an important extension of pharmacogenomics, which studies the effects of gut microbiome on drug safety and efficacy. At present, big data, Multinomial analysis, fecal bacteria transplantation, synthetic biology and other disciplines and technologies related to gut microbiome have been gradually applied in new drug development. This review introduces the current situation of new drug development and the interaction between gut microbiome and drugs, and summarizes the current research and development progress of gut microbiome related drugs.