XRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sample
Journal of Korean Medical Science
;
: 991-995, 2011.
Article
in English
| WPRIM
| ID: wpr-101529
ABSTRACT
Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroid Neoplasms
/
Case-Control Studies
/
Odds Ratio
/
Risk Factors
/
Amino Acid Substitution
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
/
DNA-Binding Proteins
/
Republic of Korea
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS