Allopregnanolone protecting cell line SH-SY5Y against 6-hydroxydopamine-induced lesion

Tong-Tong WANG; Xin YE; Wei BIAN; Zhi-Chi CHEN; Juan-Juan DU; Jun-Nan LI; Chen-You SUN; Tong-Tong WANG; Tong-Tong WANG; Xin YE; Wei BIAN; Zhi-Chi CHEN; Jun-Nan LI; Juan-Juan DU; Chen-You SUN; Wei-Da FU; Meng-Jiao CHEN

Allopregnanolone protecting cell line SH-SY5Y against 6-hydroxydopamine-induced lesion / 解剖学报

Tong-Tong WANG; Xin YE; Wei BIAN; Zhi-Chi CHEN; Juan-Juan DU; Jun-Nan LI; Chen-You SUN; Tong-Tong WANG; Tong-Tong WANG; Xin YE; Wei BIAN; Zhi-Chi CHEN; Jun-Nan LI; Juan-Juan DU; Chen-You SUN; Wei-Da FU; Meng-Jiao CHEN.

Acta Anatomica Sinica ; (6): 5-13, 2021.

Article in Chinese | WPRIM | ID: wpr-1015520

ABSTRACT

ABSTRACT

Objective To clarify the protective effect of allopregnanolone (APα) on cell line SH-SY5Y damaged by 6-hydroxydopamine (6-OHDA) and its possible molecular mechanism. Methods 6-OHDA, APα, γ-aminobutyric acid A receptor (GABAAR) antagonist, voltage-gated L-type Ca2

Allopregnanolone; Brain-derived neurotrophic factor; Calmodulin-dependent kinase II; Dopaminergic neuron; Western blotting; γ-Aminobutyric acid A receptor

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Acta Anatomica Sinica Year: 2021 Type: Article