Advancement in Aptamer-based Biosensors for Gastric Cancer and Therapeutic Strategies / 中国生物化学与分子生物学报

ABSTRACT

The timely diagnosis of early gastric cancer is important for guiding the choice of treatment and prolonging the survival of patients. However, current screening of early gastric cancer still relies on endoscopic examination due to the lack of sensitive, accurate, and convenient screening tools. The cost of large-scale screening through gastrointestinal endoscopy is high and many countries and regions cannot afford it. At present, many types of biomarkers have been proved to own the ability to predict and diagnose tumors. Aptamer, as single-stranded oligonucleotides DNA or RNA, can be used to construct sensitive and reliable biosensors based on fluorometry, colorimetric, electrochemistry, etc. through label modification, coupling with various novel materials, etc. Additionally, it is also widely used in the field of precision medicine due to its small molecular weight, high specificity, and natural biological properties. We summarized and concluded aptamer-based gastric cancer diagnostic and therapeutic studies to help researchers quickly get access to tumor-related aptamers screening process, biosensor construction and optimization methods, and therapeutic strategies. This study aimed to provide a reference for the subsequent development of gastric cancer-related aptamers that meet clinical needs and assist in the endoscopic examination, diagnosis, and follow-up.