A Compound Stomachache Capsules Against Prostate Cancer by Targeting Phosphorylated AKT1 / 中国生物化学与分子生物学报
Chinese Journal of Biochemistry and Molecular Biology
; (12): 1606-1619, 2023.
Article
in Zh
| WPRIM
| ID: wpr-1015667
Responsible library:
WPRO
ABSTRACT
The development of anticancer drugs targeting AKT1 has been reported in a variety of cancers, but there are few related studies on Chinese medicinals targeting AKT1- In this study, Compound stomachache capsules (CSC) was used for inhibiting prostate cancer (PC) cells growth by targeting AKT1 in vitro and in vivo. Through mass spectrum, target prediction and bioinformatics analysis, it is found that 37 of CSC compounds have anticancer activity, and 6 compounds such as (+)-Magnoflorine, 7-hydroxycoumarin may be their main active components against prostate cancer- The results showed that CSC had significant in vitro inhibition on the growth of prostate cancer cells (P<0- 01), and the growth inhibition rate of PC3 cells reached about 35% at 80 μg/ mL- CSC also increased ROS production, and significantly promoted apoptosis (P <0- 01) and G
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Biochemistry and Molecular Biology
Year:
2023
Type:
Article