Role of Cytoglobin in Ferroptosis Regulation / 中国生物化学与分子生物学报
Chinese Journal of Biochemistry and Molecular Biology
; (12): 1141-1148, 2022.
Article
in Zh
| WPRIM
| ID: wpr-1015785
Responsible library:
WPRO
ABSTRACT
Ferroptosis is a recently reported iron-dependent cell death, which is induced by the broken of cellular redox homeostasis and characterized by high level of lipid peroxide. More and more studies have indicated the importance of ferroptosis during disease development and prevention. As a member of globin family, cytoglobin (CYGB), also known as stellate cell activating protein (STAP), can bind to oxygen for its transportation. Moreover, CYGB contains two cysteins within its amino acid sequence and could form the S-S bond when there has change of cellular redox which will result in downstream signaling alternation. Furthermore, CYGB has nitric oxygen dioxygenase activity to scavenge excessive nitric oxygen and prevent the production of ONOO
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Biochemistry and Molecular Biology
Year:
2022
Type:
Article