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Isoflurane Inhibits Pyroptosis of Human Pulmonary Artery Smooth Muscle Cells Through the Nrf2/HO⁃1/ROS Pathway / 中国生物化学与分子生物学报
Chinese Journal of Biochemistry and Molecular Biology ; (12): 1087-1097, 2022.
Article in Chinese | WPRIM | ID: wpr-1015807
ABSTRACT
Previous studies have demonstrated that isoflurane inhale anesthesia can effectively attenuate the ischemia-reperfusion-induced pulmonary hypertension (PAH), indicating a protective effect of isoflurane on pulmonary circulation. Pulmonary artery smooth muscle cells (PASMCs) play an important role in pulmonary vascular remodeling and PAH. The abnormality of PASMC structure and function may greatly contribute to the development of PAH. This study aims to explore the effects of isoflurane on hypoxia-induced PASMC pyroptosis and the underlying mechanisms, and to find potential therapeutic target for the treatment of PAH. PASMCs were cultured at 37 ℃, 5%CO

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Biochemistry and Molecular Biology Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Biochemistry and Molecular Biology Year: 2022 Type: Article