Interaction Between Notch and Related Regulatory Signals in Promoting Wound Healing / 中国生物化学与分子生物学报

ABSTRACT

The skin is one of the most important tissues in mammals. When the skin is damaged, the damaged tissue is repaired through the physiological and psychological effects of a series of wound healing reactions to achieve tissue regeneration. The regeneration reaction mainly occurs in the early stage of embryonic development, and the wound self-healing ability weakens as the body matures. The process of tissue remodeling in mammals is more complicated. Incorrect signal guidance may cause complications and lead to abnormal wound healing. Studies have shown that the homeostasis of the wound microenvironment and the auxiliary effects of signalling molecules are important factors in healing. The Notch signaling pathway is involved in the regulation of epithelial macrophage recruitment, vascular endothelial cell regeneration and other wound healing stages. Wnt signaling promotes the proliferation of wound epidermal stem cells and the formation of vascular network structure. The Hedgehog signal drives the development of hair follicles at the wound and the regeneration of the surrounding tissues, and the TGF-beta signal contributes to the formation of multicellular layers and scar reduction during healing. This article focuses on the regulation of the Notch signaling pathway and the interaction of Notch and related signaling molecules in wound healing. We summarize the latest developments in tissue engineering research on signal molecules, analyze the signal interaction mechanism of the wound microenvironment, and provide a theoretical basis for the treatment of long-term wound healing and excessive wound healing.