Study on Relationship Between FABP Family and Risk and Prognosis of Gastric Cancer and its Function / 胃肠病学

ABSTRACT

Background: Gastric cancer is a common gastrointestinal tumor. Fatty acids play a vital role in the development of gastric cancer. The function of fatty acids requires the participation of fatty acid-binding proteins (FABPs). Aims: To systematically analyze the influence of FABPs family on risk and prognosis of gastric cancer and understand the potential role of FABPs family. Methods: The ONCOMINE database was used to analyze the differential expression of FABPs family member mRNA between gastric cancer and adjacent normal tissue, and the GEPIA database was further used for verification. The relationship between FABPs family member and survival of gastric cancer patients was analyzed. Then The Human Protein Atlas database was used to further analyze the differential expression of FABP family protein in gastric cancer. STRING and DAVID databases were used for protein-protein interaction (PPI) analysis and GO, KEGG enrichment analysis. Results: Compared with normal gastric tissue, the expressions of FABP3/4/7 in gastric cancer were significantly down-regulated, while FABP1 expression remained controversial. Survival analysis showed that patients with low expressions of FABP3/4/8 mRNA had a higher overall survival rate. GO analysis showed that FABPs family mainly enriched in biological process, cytoplasm, molecular function change. KEGG enrichment analysis showed that FABPs were mainly involved in PPAR signaling pathway, fat digestion and absorption signaling pathway. Conclusions: FABP3/4/7 can be used as risk markers and FABP3/4/8 as prognostic markers for gastric cancer. The effect of FABPs may be related to the PPAR pathway and lipid metabolism pathway.