Role of Citric Acid in Improving the Accuracy of Urea Breath Test for Diagnosis of Helicobacter pylori Infection / 胃肠病学

ABSTRACT

Urea breath test (UBT) is the most important non-invasive method for diagnosis of Helicobacter pylori (Hp) infection. Citric acid in UBT reagents can increase the acidity of stomach and the detection value of delta over baseline (DOB), thereby reducing the false positive and false negative rates of UBT in patients with gastric hypochlorhydria (moderate-to-severe gastric mucosal atrophy/intestinal metaplasia, taking proton pump inhibitors), thus improving the diagnostic accuracy of Hp infection.