Sputum bacterial culture and drug resistance of 475 patients with pneumonia / 公共卫生与预防医学

ABSTRACT

Objective To understand the distribution and drug resistance of pathogenic bacteria in sputum culture of pneumonia, and to provide evidence for the rational application of clinical antibacterial drugs . Methods The clinical data of 475 patients with positive sputum bacterial culture admitted to department of respiratory medicine of Neijiang Hospital of Traditional Chinese Medicine from May 2020 to May 2023 were collected. The types and drug resistance of pathogenic bacteria isolated from sputum culture were statistically analyzed . Results A total of 539 strains of pathogenic bacteria were isolated from the sputum culture of 475 patients with pneumonia, including 344 strains (63.82%) of Gram-negative bacteria [mainly Klebsiella pneumoniae (79 strains, 14.66%)] and 195 strains (36.18%) of Gram-positive bacteria [mainly Streptococcus pneumoniae (70 strains, 12.99%)]. Klebsiella pneumoniae was highly sensitive to aztreonam, levofloxacin, amikacin, imipenem, and ertapenem, with the sensitivity rates of 94.67%, 92.41%, 94.87%, 96.00% and 98.67% respectively. Streptococcus pneumoniae was absolutely sensitive to teicoplanin, vancomycin and linezolid, and was highly sensitive to cefpirome, levofloxacin, imipenem and ertapenem, with the sensitivity rates of 94.29%, 91.43%, 97.14% and 98.48%. Conclusions The common pathogenic bacteria of patients with pneumonia in Neijiang Hospital of Traditional Chinese Medicine include Klebsiella pneumoniae and Streptococcus pneumoniae. Various pathogenic bacteria have different degrees of resistance to common antibacterial drugs. It is necessary to combine with the types and drug susceptibility results of pathogenic bacteria for the rational application of antibacterial drugs.