Effect of Age on Glucose Metabolism of Skeletal Muscle in Rats / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 94-100, 2001.
Article
in Korean
| WPRIM
| ID: wpr-101689
ABSTRACT
BACKGROUND:
It is doubtful that aging causes deteriorated glucose metabolism and insulin resistance of skeletal muscle. Some researchers had different results about it. So we have studied the mechanism responsible for the abnormal glucose tolerance associated with aging in rapidly growing and matured rats. MATERIALS ANDMETHODS:
Animals were used S.D. rats. Growing rats were 7 weeks old (BW 160-190 gm) and matured rats were 28 weeks old (BW 420-525 gm).RESULTS:
Fasting blood glucose and plasma insulin levels were significantly elevated in matured rat compared with growing rats. And during oral glucose tolerance test the glucose level was also significantly elevated in matured rats. These results confirmed an insulin resistant state of aging. Insulin levels at 30 minutes of oral glucose tolerance test was significantly elevated in growing rat. But at 120 minutes it was maintained at higher level in matured rats than in growing rats. It suggested the possibility of increased insulin secretion by initial stimulation of beta-cells in growing rats, and increased secretion and decreased catabolic rate of insulin in matured rats. Glucose uptake rate of soleus muscle in matured rats was lower than that of growing rats, but the difference was not statistically significant. The dose(insulin)- responsive (glucose uptake) curve of soleus muscle was only slightly deviated to the right side.CONCLUSION:
Glucose metabolism of rat skeletal muscle was worsened by aging. The data of glucose uptake experiments suggested the possibility of insulin resistance of skeletal muscle in matured rats, but the mechanism of insulin resistance of skeletal muscle need further studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Blood Glucose
/
Aging
/
Insulin Resistance
/
Fasting
/
Muscle, Skeletal
/
Glucose
/
Glucose Tolerance Test
/
Insulin
/
Metabolism
Limits:
Animals
Language:
Korean
Journal:
Yeungnam University Journal of Medicine
Year:
2001
Type:
Article
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